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The Fidelity of Synaptonemal Complex Assembly Is Regulated by a Signaling Mechanism that Controls Early Meiotic Progression

Abstract:

Proper chromosome segregation during meiosis requires the assembly of the synaptonemal complex (SC) between homologous chromosomes. However, the SC structure itself is indifferent to homology, and poorly understood mechanisms that depend on conserved HORMA-domain proteins prevent ectopic SC assembly. Although HORMA-domain proteins are thought to regulate SC assembly as intrinsic components of meiotic chromosomes, here we uncover a key role for nuclear soluble HORMA-domain protein HTP-1 in the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-5406-2280
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Role:
Author
ORCID:
0000-0002-7410-3470
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Grant:
MC_U120085811
MC_U120097113
Publisher:
Cell Press Publisher's website
Journal:
Developmental Cell Journal website
Volume:
31
Issue:
4
Pages:
503-511
Publication date:
2014-11-06
Acceptance date:
2014-09-30
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
Pubs id:
pubs:502218
URN:
uri:560e8dac-e5e4-4475-9546-38fb4fec7857
UUID:
uuid:560e8dac-e5e4-4475-9546-38fb4fec7857
Local pid:
pubs:502218

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