- Abstract:
-
Proper chromosome segregation during meiosis requires the assembly of the synaptonemal complex (SC) between homologous chromosomes. However, the SC structure itself is indifferent to homology, and poorly understood mechanisms that depend on conserved HORMA-domain proteins prevent ectopic SC assembly. Although HORMA-domain proteins are thought to regulate SC assembly as intrinsic components of meiotic chromosomes, here we uncover a key role for nuclear soluble HORMA-domain protein HTP-1 in the...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1016/j.devcel.2014.10.001
-
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- Publisher:
- Cell Press Publisher's website
- Journal:
- Developmental Cell Journal website
- Volume:
- 31
- Issue:
- 4
- Pages:
- 503-511
- Publication date:
- 2014-11-06
- Acceptance date:
- 2014-09-30
- DOI:
- EISSN:
-
1878-1551
- ISSN:
-
1534-5807
- Pubs id:
-
pubs:502218
- URN:
-
uri:560e8dac-e5e4-4475-9546-38fb4fec7857
- UUID:
-
uuid:560e8dac-e5e4-4475-9546-38fb4fec7857
- Local pid:
- pubs:502218
- Copyright holder:
- Elsevier
- Copyright date:
- 2014
- Notes:
- © 2014 Elsevier Inc.
Journal article
The Fidelity of Synaptonemal Complex Assembly Is Regulated by a Signaling Mechanism that Controls Early Meiotic Progression
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