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MAPT genetic variation and neuronal maturity alter isoform expression affecting axonal transport in iPSC-derived dopamine neurons.

Abstract:

The H1 haplotype of the microtubule-associated protein tau (MAPT) locus is genetically associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects gene expression and splicing. However, the functional impact on neurons of such expression differences has yet to be fully elucidated. Here, we employ extended maturation phases during differentiation of induced pluripotent stem cells (iPSCs) into mature dopaminergic neuronal cultures to obtain cultures expressing al...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.stemcr.2017.06.005

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Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
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Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
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Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
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Parkinson’s UK More from this funder
Oxford Martin School More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Stem Cell Reports Journal website
Volume:
9
Issue:
2
Pages:
587-599
Publication date:
2017-07-05
Acceptance date:
2017-06-06
DOI:
EISSN:
2213-6711
Pubs id:
pubs:707881
URN:
uri:560d2512-e22f-4879-84c5-ff865ba4272c
UUID:
uuid:560d2512-e22f-4879-84c5-ff865ba4272c
Local pid:
pubs:707881
Language:
English
Keywords:

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