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Examining the role of chromatin modifying enzymes in medulloblastoma by utilizing a chemical library

Abstract:

Medulloblastoma (MB) is the most common paediatric brain tumor that arises during infancy and childhood and is a major cause of cancer related-morbidity and mortality in children. Recently, medulloblastomas are described as four distinct molecular subgroups (Wnt, sonic hedgehog, Group 3 and Group 4), which have distinct transcriptional, cytogenetic, and mutational spectra. Next-generation studies have revealed that adult medulloblastomas involve remarkably more somatic SNVs and indels than pa...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/S0959-8049(16)32730-7

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
St Catherines College
Role:
Author
Publisher:
Elsevier Publisher's website
Publication date:
2016-12-09
DOI:
ISSN:
1879-0852 and 0959-8049
Pubs id:
pubs:719762
URN:
uri:56045826-a705-41ab-8e9b-f617fe18b2df
UUID:
uuid:56045826-a705-41ab-8e9b-f617fe18b2df
Local pid:
pubs:719762

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