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Extensive weight loss reduces glycan age by altering IgG N-glycosylation

Abstract:

Background
Obesity, a major global health problem, is associated with increased cardiometabolic morbidity and mortality. Protein glycosylation is a frequent posttranslational modification, highly responsive to inflammation and ageing. The prospect of biological age reduction, by changing glycosylation patterns through metabolic intervention, opens many possibilities. We have investigated whether weight loss interventions affect inflammation- and ageing-associated IgG g...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41366-021-00816-3

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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-0155-1846
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Role:
Author
ORCID:
0000-0002-7134-2484
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Role:
Author
ORCID:
0000-0003-3174-120X
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Institution:
University of Oxford
Role:
Author
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Institution:
Oxford University Hospitals
Role:
Author
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Name:
Medical Research Council
Grant:
MR/P011462/1
Publisher:
Springer Nature
Journal:
International Journal of Obesity More from this journal
Volume:
45
Issue:
7
Pages:
1521-1531
Publication date:
2021-05-03
Acceptance date:
2021-04-09
DOI:
EISSN:
1476-5497
ISSN:
0307-0565
Pmid:
33941843
Language:
English
Keywords:
Pubs id:
1175875
Local pid:
pubs:1175875
Deposit date:
2023-01-16

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