Journal article icon

Journal article

T-cell immunity to Kaposi sarcoma-associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cells.

Abstract:

T-cell immunity is important for controlling Kaposi sarcoma-associated herpesvirus (KSHV) diseases such as the endothelial cell malignancy Kaposi sarcoma, or the B-cell malignancy, primary effusion lymphoma (PEL). However, little is known about KSHV-specific T-cell immunity in healthy donors and immune control of disease. Using PBMCs from healthy KSHV-infected donors, we found weak ex vivo responses to the KSHV latent antigens LANA, vFLIP, vCyclin, and Kaposin, with LANA most frequently recog...

Expand abstract

Actions


Access Document


Authors


de Silva, T More by this author
Ahasan, MM More by this author
Expand authors...
Journal:
Blood
Volume:
119
Issue:
9
Pages:
2083-2092
Publication date:
2012-03-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:55fc9723-4803-4c0b-acf9-c249e1a3c2e0
Source identifiers:
237458
Local pid:
pubs:237458

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP