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Journal article

Stem cell plasticity and niche dynamics in cancer progression

Abstract:

Objective

Cancer stem cells (CSCs) have been hypothesized to initiate and drive tumor growth and recurrence due to their self-renewal ability. If correct, this hypothesis implies that successful therapy must focus primarily on eradication of this CSC fraction. However, recent evidence suggests stemness is niche dependent and may represent one of many phenotypic states that can be accessed by many cancer genotypes when presented with specific environmental cues. A better understan...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1109/TBME.2016.2607183

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Publisher:
Institute of Electrical and Electronics Engineers Publisher's website
Journal:
IEEE Transactions on Biomedical Engineering Journal website
Volume:
64
Issue:
3
Pages:
528-537
Publication date:
2016-09-05
Acceptance date:
2016-08-28
DOI:
ISSN:
1558-2531 and 0018-9294
Pubs id:
pubs:648479
URN:
uri:55fc12b2-9b8c-40e2-9bfd-112fe633b714
UUID:
uuid:55fc12b2-9b8c-40e2-9bfd-112fe633b714
Local pid:
pubs:648479

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