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Journal article

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms.

Abstract:

Large-scale sequencing of genomes has revealed that most enzyme families include inactive homologues. These pseudoenzymes are often well conserved, implying a selective pressure to retain them during evolution, and therefore that they have significant function. Mechanistic insights and evolutionary lessons are now emerging from the study of a broad range of such 'dead' enzymes. The recently discovered iRhoms - inactive homologues of rhomboid proteases - have joined derlins and other members o...

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Publication status:
Published

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Publisher copy:
10.1038/nrm3392

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Nature reviews. Molecular cell biology
Volume:
13
Issue:
8
Pages:
489-498
Publication date:
2012-08-05
DOI:
EISSN:
1471-0080
ISSN:
1471-0072
URN:
uuid:55f7de29-5a51-4e31-a1c9-efda4d38a07f
Source identifiers:
356099
Local pid:
pubs:356099

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