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The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes

Abstract:

Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural infection. However, corresponding viral regions are highly variable at a population level, with a reduction in T-cell reactivity to these variants. We therefore designed and manufactured second generation simia...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.vaccine.2017.10.079

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Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
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Oxford Martin School More from this funder
Publisher:
Elsevier Ltd Publisher's website
Journal:
Vaccine Journal website
Volume:
36
Issue:
2
Pages:
313-321
Publication date:
2017-12-02
Acceptance date:
2017-10-26
DOI:
ISSN:
1873-2518 and 0264-410X
Pubs id:
pubs:811139
URN:
uri:55ef8faa-03ad-4630-b738-0e5360f21d49
UUID:
uuid:55ef8faa-03ad-4630-b738-0e5360f21d49
Local pid:
pubs:811139

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