Journal article
The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes
- Abstract:
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Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural infection. However, corresponding viral regions are highly variable at a population level, with a reduction in T-cell reactivity to these variants. We therefore designed and manufactured second generation simia...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.0MB)
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- Publisher copy:
- 10.1016/j.vaccine.2017.10.079
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Authors
Funding
Oxford Martin School
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Vaccine Journal website
- Volume:
- 36
- Issue:
- 2
- Pages:
- 313-321
- Publication date:
- 2017-12-02
- Acceptance date:
- 2017-10-26
- DOI:
- ISSN:
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0264-410X and 1873-2518
- Pmid:
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29203182
- Source identifiers:
-
811139
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:811139
- UUID:
-
uuid:55ef8faa-03ad-4630-b738-0e5360f21d49
- Local pid:
- pubs:811139
- Deposit date:
- 2017-12-19
Terms of use
- Copyright holder:
- von Delft et al
- Copyright date:
- 2017
- Notes:
-
Copyright 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://
creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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