- Abstract:
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Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural infection. However, corresponding viral regions are highly variable at a population level, with a reduction in T-cell reactivity to these variants. We therefore designed and manufactured second generation simia...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.0MB)
-
- Publisher copy:
- 10.1016/j.vaccine.2017.10.079
-
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- Publisher:
- Elsevier Ltd Publisher's website
- Journal:
- Vaccine Journal website
- Volume:
- 36
- Issue:
- 2
- Pages:
- 313-321
- Publication date:
- 2017-12-02
- Acceptance date:
- 2017-10-26
- DOI:
- ISSN:
-
1873-2518 and 0264-410X
- Pubs id:
-
pubs:811139
- URN:
-
uri:55ef8faa-03ad-4630-b738-0e5360f21d49
- UUID:
-
uuid:55ef8faa-03ad-4630-b738-0e5360f21d49
- Local pid:
- pubs:811139
- Language:
- English
- Keywords:
- Copyright holder:
- von Delft et al.
- Copyright date:
- 2017
- Notes:
-
Copyright 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://
creativecommons.org/licenses/by/4.0/).
Journal article
The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes
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Oxford Martin School
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