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Site-selective glycosylation of proteins: creating synthetic glycoproteins.

Abstract:

In higher organisms, the functions of many proteins are modulated by post-translational modifications (PTMs). Glycosylation is by far the most diverse of the PTM processes. Natural protein production methods typically produce PTM or glycoform mixtures within which function is difficult to dissect or control. Chemical tagging methods allow the precise attachment of multiple glycosylation modifications to bacterially expressed (bare) protein scaffolds, allowing reconstitution of functionally ef...

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Publication status:
Published

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Publisher copy:
10.1038/nprot.2007.430

Authors


van Kasteren, SI More by this author
Kramer, HB More by this author
Gamblin, DP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Nature protocols
Volume:
2
Issue:
12
Pages:
3185-3194
Publication date:
2007
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
URN:
uuid:55e380d6-f8c5-4218-aba8-436958d2277c
Source identifiers:
34078
Local pid:
pubs:34078

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