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Thesis

The spatiotemporal dynamics of neural activity in the neocortex during waking and sleep in mice

Abstract:

Sleep is a non-homogenous physiological and behavioural state, which is regulated at many distinct levels, some of which are the focus of this project. The first objective of this project was to investigate cortical EEG dynamics at vigilance state transitions. The experiments have been carried out in adult male C57BL/6 mice, implanted with EEG screws and electromyography (EMG) wires. The main novel finding was that following REM sleep episodes, cortical activity during the initial NREM sle...

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Department:
University of Oxford
Role:
Supervisor
Role:
Supervisor
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Grant:
MR/L003635/1
Funding agency for:
Project
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Grant:
PCIG11-GA-2012-322050
Funding agency for:
Project
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Grant:
098461/Z/12/Z
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English

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