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Supercoiling of DNA and nuclear conformation during the cell-cycle.

Abstract:

When cells are lysed in solutions containing high concentrations of salt and a non-ionic detergent, structures are released which retain many of the morphological features of nuclei. These nucleoids contain superhelical DNA but are depleted of nuclear protein. We have analysed DNA conformation in nucleoids derived from HeLa cells synchronized at different stages in the cell cycle. The gross differences in nuclear morphology seen during the cell cycle are reflected in the morphology of the nuc...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
30
Issue:
APR
Pages:
211-226
Publication date:
1978-04-05
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:55cb0a79-e824-42ed-b55e-a53ceabf085a
Source identifiers:
27867
Local pid:
pubs:27867

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