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Septo-hippocampal deafferentation protects CA1 neurons against ischemic injury.

Abstract:

Excessive synaptic excitation caused by transient cerebral ischemia has been proposed to explain the greater vulnerability of specific neuronal populations to ischemic injury. We tested this hypothesis in rats by cutting, alone or in combination, the afferent fibers that travel in the fimbria/fornix, the perforant, or the Schäffer collateral pathways and innervate the right CA1 hippocampus. Seven to twelve days later the animals were subjected to 30 min of reversible forebrain ischemia. Irrev...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Pulsinelli, WA More by this author
Journal:
Brain research
Volume:
512
Issue:
1
Pages:
7-14
Publication date:
1990-03-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:55ae09dd-69ad-416a-baea-2456c6b5ce59
Source identifiers:
84259
Local pid:
pubs:84259

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