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Different populations of RNA polymerase II in living mammalian cells.

Abstract:

RNA polymerase II is responsible for transcription of most eukaryotic genes, but, despite exhaustive analysis, little is known about how it transcribes natural templates in vivo. We studied polymerase dynamics in living Chinese hamster ovary cells using an established line that expresses the largest (catalytic) subunit of the polymerase (RPB1) tagged with the green fluorescent protein (GFP). Genetic complementation has shown this tagged polymerase to be fully functional. Fluorescence loss in ...

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Publication status:
Published

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Publisher copy:
10.1007/s10577-005-7720-1

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
Volume:
13
Issue:
2
Pages:
135-144
Publication date:
2005-01-01
DOI:
EISSN:
1573-6849
ISSN:
0967-3849
URN:
uuid:55acf1e5-096a-4fd1-b5fa-3185c77ba310
Source identifiers:
15631
Local pid:
pubs:15631

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