Journal article

Asymmetric synthesis of moiramide B

Abstract:: The first asymmetric synthesis of Moiramide B 1 is achieved using lithium amide 4 and pyrrolidinone auxiliary 5; pyrrolidinone auxiliary 5 is used to create the novel (S)-2-methyl-N-benzyloxysuccinimide 15 which is subsequently acylated with the highly reactive tert-butoxycarbonyl-protected N-carboxanhydride of L-valine (Boc-Val-NCA) under strongly basic conditions, without racemization, while lithium amide 4 is used to synthesize homochiral D-β-phenylalanine tert-butyl ester 8.

Publication status:: Published

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APA Style

Dixon, D., & Davies, S. (1996). Asymmetric synthesis of moiramide B. CHEMICAL COMMUNICATIONS, 15, 1797–1798.

MLA Style

Dixon, D., and S. Davies. “Asymmetric Synthesis of Moiramide B.” CHEMICAL COMMUNICATIONS, no. 15, 1996, pp. 1797–98.

Chicago Style

Dixon, D, and S Davies. 1996. “Asymmetric Synthesis of Moiramide B.” CHEMICAL COMMUNICATIONS, no. 15: 1797–98.
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Publisher copy:: 10.1039/cc9960001797

Authors

+ Dixon, D More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Davies, S More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: CHEMICAL COMMUNICATIONS More from this journal
Issue:: 15
Pages:: 1797-1798
Publication date:: 1996-08-07
DOI:: 10.1039/cc9960001797
EISSN:: 1364-548X
ISSN:: 1359-7345

Language:: English
Pubs id:: pubs:45342
UUID:: uuid:55a1d71e-eefc-42b2-b265-5f2b0f55e01f
Local pid:: pubs:45342
Source identifiers:: 45342
Deposit date:: 2012-12-19

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Copyright date:: 1996

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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