Journal article icon

Journal article

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Abstract:

Fully activated innate immune cells are required for effective responses to infection, but their prompt deactivation and removal are essential for limiting tissue damage. Here, we have identified a critical role for the prolyl hydroxylase enzyme Phd2 in maintaining the balance between appropriate, predominantly neutrophil-mediated pathogen clearance and resolution of the innate immune response. We demonstrate that myeloid-specific loss of Phd2 resulted in an exaggerated inflammatory response ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1172/jci90848

Authors


Willson, JA More by this author
Dickinson, RS More by this author
Harris, AJ More by this author
Expand authors...
More from this funder
Funding agency for:
Willson, JA
More from this funder
Funding agency for:
Dickinson, RS
More from this funder
Funding agency for:
Thompson, AAR
More from this funder
Funding agency for:
Thompson, AAR
Expand funders...
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
127
Issue:
9
Pages:
3407-3420
Publication date:
2017-08-14
Acceptance date:
2017-06-29
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pubs id:
pubs:721560
URN:
uri:558e1178-071e-4793-ac3b-f4b6056ea43a
UUID:
uuid:558e1178-071e-4793-ac3b-f4b6056ea43a
Local pid:
pubs:721560
Paper number:
9
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP