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Journal article

Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.

Abstract:

OBJECTIVE: The causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear. We aimed to use Mendelian randomization to test the hypothesis that raised circulating triglyceride levels causally influence the risk of type 2 diabetes and raise normal fasting glucose levels and hepatic insulin resistance. RESEARCH DESIGN AND METHODS: We tested 10 common genetic variants robustly associated with circulating triglyceride levels against the type...

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Publication status:
Published

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Publisher copy:
10.2337/db10-1317

Authors


De Silva, NM More by this author
Freathy, RM More by this author
Palmer, TM More by this author
Donnelly, LA More by this author
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Journal:
Diabetes
Volume:
60
Issue:
3
Pages:
1008-1018
Publication date:
2011-03-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:55824064-214b-4f97-9313-060567358018
Source identifiers:
127439
Local pid:
pubs:127439

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