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Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour.

Abstract:

RATIONALE: Altered serotonergic and dopaminergic function have been widely implicated in behavioural disorders associated with impulsivity and risk-taking. However, little research has addressed the specific cognitive consequences of changed monoaminergic function that might contribute to the production of impulsive behaviour. OBJECTIVES AND METHODS: We compared the effects of rapid plasma tryptophan depletion, acute doses of the mixed indirect catecholamine agonist, methylphenidate (40 mg), ...

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Publication status:
Published

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Publisher copy:
10.1007/pl00005494

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Blackshaw, AJ More by this author
Middleton, HC More by this author
Matthews, K More by this author
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Journal:
Psychopharmacology
Volume:
146
Issue:
4
Pages:
482-491
Publication date:
1999-10-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:5571ca46-15c8-4837-b153-8e070067f4ff
Source identifiers:
223171
Local pid:
pubs:223171

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