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Practical approaches to Bayesian sample size determination in non-inferiority trials with binary outcomes

Abstract:

Bayesian analysis of a non-inferiority trial is advantageous in allowing direct probability statements to be made about the relative treatment difference rather than relying on an arbitrary and often poorly justified non-inferiority margin. When the primary analysis will be Bayesian, a Bayesian approach to sample size determination will often be appropriate for consistency with the analysis. We demonstrate three Bayesian approaches to choosing sample size for non-inferiority trials with bi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1002/sim.9661

Authors


Publisher:
Wiley
Journal:
Statistics in Medicine More from this journal
Volume:
42
Issue:
8
Pages:
1127-1138
Publication date:
2023-01-20
Acceptance date:
2022-12-20
DOI:
EISSN:
1097-0258
ISSN:
0277-6715
Language:
English
Keywords:
Pubs id:
1319602
Local pid:
pubs:1319602
Deposit date:
2023-01-10

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