Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes.

Alcover, A; Alberini, C; Acuto, O; Clayton, LK; Transy, C; Spagnoli, GC; Moingeon, P; Lopez, P; Reinherz, EL

Abstract:

Human T lymphocytes can be activated through either the antigen/MHC receptor complex T3-Ti (CD3-Ti) or the T11 (CD2) molecule to proliferate via an IL-2 dependent mechanism. To investigate the relationship of these pathways to one another, we generated and characterized Jurkat mutants which selectively express either surface CD3-Ti or CD2. Here we show that CD3-Ti- mutants fail to be stimulated by either pathway to increase phosphoinositide turnover, mobilize calcium or induce the IL-2 gene. ...

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APA Style

Alcover, A., Alberini, C., Acuto, O., Clayton, L. K., Transy, C., Spagnoli, G. C., Moingeon, P., Lopez, P., & Reinherz, E. L. (1988). Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes. The EMBO Journal, 7(7), 1973–1977.

MLA Style

Alcover, A., et al. “Interdependence of CD3-Ti and CD2 Activation Pathways in Human T Lymphocytes.” The EMBO Journal, vol. 7, no. 7, 1988, pp. 1973–77.

Chicago Style

Alcover, A, C Alberini, O Acuto, LK Clayton, C Transy, GC Spagnoli, P Moingeon, P Lopez, and EL Reinherz. 1988. “Interdependence of CD3-Ti and CD2 Activation Pathways in Human T Lymphocytes.” The EMBO Journal 7 (7): 1973–77.
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