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Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes.

Abstract:

Human T lymphocytes can be activated through either the antigen/MHC receptor complex T3-Ti (CD3-Ti) or the T11 (CD2) molecule to proliferate via an IL-2 dependent mechanism. To investigate the relationship of these pathways to one another, we generated and characterized Jurkat mutants which selectively express either surface CD3-Ti or CD2. Here we show that CD3-Ti- mutants fail to be stimulated by either pathway to increase phosphoinositide turnover, mobilize calcium or induce the IL-2 gene. ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
The EMBO journal
Volume:
7
Issue:
7
Pages:
1973-1977
Publication date:
1988-07-05
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:5564feea-ae0e-421d-a68f-0ed2c6f59246
Source identifiers:
25570
Local pid:
pubs:25570

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