Journal article
Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes.
- Abstract:
-
Human T lymphocytes can be activated through either the antigen/MHC receptor complex T3-Ti (CD3-Ti) or the T11 (CD2) molecule to proliferate via an IL-2 dependent mechanism. To investigate the relationship of these pathways to one another, we generated and characterized Jurkat mutants which selectively express either surface CD3-Ti or CD2. Here we show that CD3-Ti- mutants fail to be stimulated by either pathway to increase phosphoinositide turnover, mobilize calcium or induce the IL-2 gene. ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- EMBO journal
- Volume:
- 7
- Issue:
- 7
- Pages:
- 1973-1977
- Publication date:
- 1988-07-01
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- Source identifiers:
-
25570
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:25570
- UUID:
-
uuid:5564feea-ae0e-421d-a68f-0ed2c6f59246
- Local pid:
- pubs:25570
- Deposit date:
- 2012-12-19
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- Copyright date:
- 1988
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