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Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial.

Abstract:

BACKGROUND: Artemisinin-combination therapy (ACT) is recommended as first-line treatment of falciparum malaria throughout the world, and fixed-dose combinations are preferred by WHO; whether a single gametocytocidal dose of primaquine should be added is unknown. We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the addition of a single gametocytocidal dose of primaquine. METHODS: In an open-label randomised trial ...

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Publication status:
Published

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Journal:
The Lancet. Infectious diseases
Volume:
10
Issue:
10
Pages:
673-681
Publication date:
2010-10-05
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:55602632-9f18-49a5-b70b-91d1f22766bd
Source identifiers:
95477
Local pid:
pubs:95477

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