Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial.

Journal article

BACKGROUND: Artemisinin-combination therapy (ACT) is recommended as first-line treatment of falciparum malaria throughout the world, and fixed-dose combinations are preferred by WHO; whether a single gametocytocidal dose of primaquine should be added is unknown. We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the addition of a single gametocytocidal dose of primaquine. METHODS: In an open-label randomised trial ...

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Authors: Smithuis, F; Kyaw, M; Phe, O; Win, T; Aung, P

• Publication status: Published
• Journal: Lancet. Infectious diseases
• Volume: 10
• Issue: 10
• Pages: 673-681
• Publication date: 2010-10-01
• DOI: 10.1016/s1473-3099(10)70187-0
• EISSN: 1474-4457
• ISSN: 1473-3099
• Language: English
• Keywords: Treatment Outcome; Female; Humans; Young Adult; Child, Preschool; Mefloquine; Malaria, Falciparum; Primaquine; Infant; Malaria, Vivax; Myanmar; Artemisinins; Middle Aged; Adult; Male; Aged; Drug Therapy, Combination; Adolescent; Antimalarials; Plasmodium falciparum; Child; Aged, 80 and over