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A global sensitivity tool for cardiac cell modeling: Application to ionic current balance and hypertrophic signaling.

Abstract:

Cardiovascular diseases are the major cause of death in the developed countries. Identifying key cellular processes involved in generation of the electrical signal and in regulation of signal transduction pathways is essential for unraveling the underlying mechanisms of heart rhythm behavior. Computational cardiac models provide important insights into cardiovascular function and disease. Sensitivity analysis presents a key tool for exploring the large parameter space of such models, in order...

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Publication status:
Published

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Publisher copy:
10.1109/iembs.2010.5626841

Authors


Cooling, MT More by this author
Bethwaite, B More by this author
Peachey, T More by this author
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Journal:
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
Volume:
2010
Pages:
1498-1502
Publication date:
2010
DOI:
ISSN:
1557-170X
URN:
uuid:555f03dd-e7a4-4262-b4c7-69f2a108ced9
Source identifiers:
237385
Local pid:
pubs:237385

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