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Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index

Abstract:

The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward fo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pgen.1004508

Authors


Hoggart, CJ More by this author
Venturini, G More by this author
Mangino, M More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
10
Issue:
7
Pages:
ARTN e1004508
Publication date:
2014-07-31
Acceptance date:
2014-05-14
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:555c7e8a-041a-4cb8-aa4d-78b5052a6ead
Source identifiers:
480635
Local pid:
pubs:480635
Language:
English
Keywords:

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