Journal article
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index
- Abstract:
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The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward fo...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 536.5KB)
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- Publisher copy:
- 10.1371/journal.pgen.1004508
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Volume:
- 10
- Issue:
- 7
- Pages:
- ARTN e1004508
- Publication date:
- 2014-07-31
- Acceptance date:
- 2014-05-14
- DOI:
- EISSN:
-
1553-7404
- ISSN:
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1553-7390
- Source identifiers:
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480635
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:480635
- UUID:
-
uuid:555c7e8a-041a-4cb8-aa4d-78b5052a6ead
- Local pid:
- pubs:480635
- Deposit date:
- 2014-08-22
Terms of use
- Copyright holder:
- Hoggart et al
- Copyright date:
- 2014
- Notes:
- Copyright: © 2014 Hoggart et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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