- Abstract:
-
The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward fo...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 536.5kb)
-
- Publisher copy:
- 10.1371/journal.pgen.1004508
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Volume:
- 10
- Issue:
- 7
- Pages:
- ARTN e1004508
- Publication date:
- 2014-07-31
- Acceptance date:
- 2014-05-14
- DOI:
- EISSN:
-
1553-7404
- ISSN:
-
1553-7390
- URN:
-
uuid:555c7e8a-041a-4cb8-aa4d-78b5052a6ead
- Source identifiers:
-
480635
- Local pid:
- pubs:480635
- Language:
- English
- Keywords:
- Copyright holder:
- Hoggart et al.
- Copyright date:
- 2014
- Notes:
- Copyright: © 2014 Hoggart et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index
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