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Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation

Abstract:

Channelling of glucose via glycogen, known as the glycogen shunt, may play an important role in the metabolism of brain tumours, especially in hypoxic conditions. We aimed to dissect the role of glycogen degradation in glioblastoma (GBM) response to ionising radiation (IR). Knockdown of the glycogen phosphorylase liver isoform (PYGL), but not the brain isoform (PYGB), decreased clonogenic growth and survival of GBM cell lines and sensitised them to IR doses of 10–12 Gy. Two to five days af...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41419-022-05005-2

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0000-0001-5850-5907
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-2339-0721
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Role:
Author
ORCID:
0000-0001-6685-5480
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0001-8646-062X
More by this author
Institution:
University of Oxford
Role:
Author
Publisher:
Springer Nature
Journal:
Cell Death and Disease More from this journal
Volume:
13
Issue:
6
Article number:
573
Place of publication:
England
Publication date:
2022-06-28
Acceptance date:
2022-06-08
DOI:
EISSN:
2041-4889
Pmid:
35764612
Language:
English
Keywords:
Pubs id:
1267035
Local pid:
pubs:1267035
Deposit date:
2022-11-11

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