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Cortical lesions and HLA genotype: Still a grey area?

Abstract:

Substantial evidence suggests that cortical tissue injury plays a key role in the progression of permanent disability in multiple sclerosis (MS). Cortical demyelination occurs early, becomes more extensive with time and eventually exceeds the extent of white matter pathology in progressive disease. However our understanding of the mechanisms driving cortical demyelination remains poor. As a result, we lack the therapeutic targets that could enable cortical disease burden to be reduced and dis...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/1352458517734071

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Divisional Administration, MSD Office
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Divisional Administration, MSD Office
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Publisher:
SAGE Publication Publisher's website
Journal:
Multiple Sclerosis Journal website
Publication date:
2017-10-10
Acceptance date:
2017-08-23
DOI:
EISSN:
1477-0970
ISSN:
1352-4585
Pubs id:
pubs:735148
URN:
uri:554743b8-046d-4c63-a247-0ecde449ea09
UUID:
uuid:554743b8-046d-4c63-a247-0ecde449ea09
Local pid:
pubs:735148
Language:
English
Keywords:

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