Journal article
Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements.
- Abstract:
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The TNF locus on chromosome 6p21 encodes a family of proteins with key roles in the immune response whose dysregulation leads to severe disease. Transcriptional regulation is important, with cell type and stimulus-specific enhancer complexes involving the proximal TNF promoter. We show how quantitative chromatin profiling across a 34 kb region spanning the TNF locus has allowed us to identify a number of novel DNase hypersensitive sites and characterize more distant regulatory elements. We de...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Nucleic acids research More from this journal
- Volume:
- 36
- Issue:
- 15
- Pages:
- 4845-4862
- Publication date:
- 2008-09-01
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
Item Description
- Language:
-
English
- Keywords:
- UUID:
-
uuid:5539a033-8e82-4819-997e-83d6b166455a
- Local pid:
-
pubs:28082
- Source identifiers:
-
28082
- Deposit date:
-
2012-12-19
Terms of use
- Copyright holder:
- Taylor et al
- Copyright date:
- 2008
- Notes:
- Copyright © 2008 Taylor et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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