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Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements.

Abstract:

The TNF locus on chromosome 6p21 encodes a family of proteins with key roles in the immune response whose dysregulation leads to severe disease. Transcriptional regulation is important, with cell type and stimulus-specific enhancer complexes involving the proximal TNF promoter. We show how quantitative chromatin profiling across a 34 kb region spanning the TNF locus has allowed us to identify a number of novel DNase hypersensitive sites and characterize more distant regulatory elements. We de...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkn444

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Molecular Medicine, WTC Human Genetics
Role:
Author
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Funding agency for:
Knight, JC
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
36
Issue:
15
Pages:
4845-4862
Publication date:
2008-09-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:5539a033-8e82-4819-997e-83d6b166455a
Source identifiers:
28082
Local pid:
pubs:28082

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