Journal article
Molecular insights into substrate specificity of prostate specific antigen through structural modeling.
- Abstract:
-
Prostate Specific Antigen's (PSA) role as a biomarker for prostate cancer is well established but the physiological role of its serine protease activity in the pathobiology of normal prostate and prostate carcinogenesis remains largely unknown. In light of recent studies that implicate PSA's enzymatic activity in the initiation and/or progression of prostate cancer, we performed a molecular modeling study of substrate binding at the catalytic site of PSA wherein a PSA-selective substrate (HSS...
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- Publisher copy:
- 10.1002/prot.22524
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Authors
Bibliographic Details
- Journal:
- Proteins
- Volume:
- 77
- Issue:
- 4
- Pages:
- 984-993
- Publication date:
- 2009-12-01
- DOI:
- EISSN:
-
1097-0134
- ISSN:
-
0887-3585
- Source identifiers:
-
365909
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:365909
- UUID:
-
uuid:55399c99-5998-45d0-be76-a753a815a751
- Local pid:
- pubs:365909
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2009
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