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Molecular insights into substrate specificity of prostate specific antigen through structural modeling.

Abstract:

Prostate Specific Antigen's (PSA) role as a biomarker for prostate cancer is well established but the physiological role of its serine protease activity in the pathobiology of normal prostate and prostate carcinogenesis remains largely unknown. In light of recent studies that implicate PSA's enzymatic activity in the initiation and/or progression of prostate cancer, we performed a molecular modeling study of substrate binding at the catalytic site of PSA wherein a PSA-selective substrate (HSS...

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Publisher copy:
10.1002/prot.22524

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Proteins
Volume:
77
Issue:
4
Pages:
984-993
Publication date:
2009-12-05
DOI:
EISSN:
1097-0134
ISSN:
0887-3585
URN:
uuid:55399c99-5998-45d0-be76-a753a815a751
Source identifiers:
365909
Local pid:
pubs:365909

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