Journal article
RNA helicase DDX1 converts RNA G-quadruplex structures into R-Loops to promote IgH class switch recombination
- Abstract:
-
Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is associated with the formation of R-loop structures over switch (S) regions. While these often occur co-transcriptionally between nascent RNA and template DNA, we now show that they also form as part of a post-transcriptional mechanism targeting AID to IgH S-regions. This depends on the RNA helicase DDX1 that is also required for CSR in vivo. DDX1 binds to G-quadruplex (G4) structures present in intronic switch t...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Publisher copy:
- 10.1016/j.molcel.2018.04.001
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
European Molecular Biology Organization
More from this funder
Bibliographic Details
- Publisher:
- ScienceDirect Publisher's website
- Journal:
- Molecular Cell Journal website
- Volume:
- 70
- Issue:
- 4
- Pages:
- 650-662.e8
- Publication date:
- 2018-05-03
- Acceptance date:
- 2018-03-30
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- Pmid:
-
29731414
- Source identifiers:
-
847745
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:847745
- UUID:
-
uuid:553054b7-bc0f-4ebe-859c-bb22920fa08b
- Local pid:
- pubs:847745
- Deposit date:
- 2018-05-22
Terms of use
- Copyright holder:
- Proudfoot et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Author(s). Published by Elsevier Inc.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
If you are the owner of this record, you can report an update to it here: Report update to this record