- Abstract:
-
Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is associated with the formation of R-loop structures over switch (S) regions. While these often occur co-transcriptionally between nascent RNA and template DNA, we now show that they also form as part of a post-transcriptional mechanism targeting AID to IgH S-regions. This depends on the RNA helicase DDX1 that is also required for CSR in vivo. DDX1 binds to G-quadruplex (G4) structures present in intronic switch t...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Publisher copy:
- 10.1016/j.molcel.2018.04.001
-
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- Publisher:
- ScienceDirect Publisher's website
- Journal:
- Molecular Cell Journal website
- Volume:
- 70
- Issue:
- 4
- Pages:
- 650-662.e8
- Publication date:
- 2018-05-03
- Acceptance date:
- 2018-03-30
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- Pubs id:
-
pubs:847745
- URN:
-
uri:553054b7-bc0f-4ebe-859c-bb22920fa08b
- UUID:
-
uuid:553054b7-bc0f-4ebe-859c-bb22920fa08b
- Local pid:
- pubs:847745
- Language:
- English
- Keywords:
- Copyright holder:
- Proudfoot et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Author(s). Published by Elsevier Inc.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Journal article
RNA helicase DDX1 converts RNA G-quadruplex structures into R-Loops to promote IgH class switch recombination
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European Molecular Biology Organization
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