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RNA helicase DDX1 converts RNA G-quadruplex structures into R-Loops to promote IgH class switch recombination

Abstract:

Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is associated with the formation of R-loop structures over switch (S) regions. While these often occur co-transcriptionally between nascent RNA and template DNA, we now show that they also form as part of a post-transcriptional mechanism targeting AID to IgH S-regions. This depends on the RNA helicase DDX1 that is also required for CSR in vivo. DDX1 binds to G-quadruplex (G4) structures present in intronic switch t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Magdalen College
Role:
Author
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European Molecular Biology Organization More from this funder
Publisher:
ScienceDirect Publisher's website
Journal:
Molecular Cell Journal website
Volume:
70
Issue:
4
Pages:
650-662.e8
Publication date:
2018-05-03
Acceptance date:
2018-03-30
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pubs id:
pubs:847745
URN:
uri:553054b7-bc0f-4ebe-859c-bb22920fa08b
UUID:
uuid:553054b7-bc0f-4ebe-859c-bb22920fa08b
Local pid:
pubs:847745

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