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A common variant at the 14q32 endometrial cancer risk locus activates AKT1 through YY1 binding

Abstract:

A recent meta-analysis of multiple genome-wide association and follow-up endometrial cancer case-control datasets identified a novel genetic risk locus for this disease at chromosome 14q32.33. To prioritize the functional SNP(s) and target gene(s) at this locus, we employed an in silico fine-mapping approach using genotyped and imputed SNP data for 6,608 endometrial cancer cases and 37,925 controls of European ancestry. Association and functional analyses provide evidence that the best candid...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ajhg.2016.04.012

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Funding agency for:
Tomlinson, I
Publisher:
Cell Press Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
98
Issue:
6
Pages:
1159-1169
Publication date:
2016-06-05
Acceptance date:
2016-04-19
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Pubs id:
pubs:625683
URN:
uri:552a9fcd-60a5-4a7e-b58d-a655a415bca2
UUID:
uuid:552a9fcd-60a5-4a7e-b58d-a655a415bca2
Local pid:
pubs:625683
Paper number:
6
Language:
English
Keywords:

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