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Virus-induced immunosuppression. 1. Age at infection relates to a selective or generalized defect.

Abstract:

Viruses that persist must develop strategies to escape immunologic surveillance in order to survive. Investigation of lymphocytic choriomeningitis virus (LCMV)-induced persistence has indicated that this virus avoids immune clearance mainly by aborting the viral specific cytotoxic T lymphocyte (CTL) response, a response that is necessary for terminating viral infection. This study demonstrates that persistence established in immunologically immature newborns selectively depletes the LCMV-spec...

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Publication status:
Published

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Publisher copy:
10.1006/viro.1993.1389

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
Journal:
Virology
Volume:
195
Issue:
2
Pages:
397-405
Publication date:
1993-08-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:551bb25e-9094-4e41-bc89-addc22c0581f
Source identifiers:
35852
Local pid:
pubs:35852

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