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Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms.

Abstract:

Chronic exposure to elevated levels of glucocorticoids leads to metabolic dysfunctions with hyperglycemia and insulin resistance. Long-term treatment with glucocorticoids induces severe impairment of glucose-stimulated insulin secretion. We analyzed the effects of short-, and medium-term (2-120h) treatment with 50-200nM glucocorticoids on primary pancreatic islet cultures derived from lean C57BL/6J mice. In contrast to animal models of insulin resistance, beta-cells from lean mice respond wit...

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Publication status:
Published

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Publisher copy:
10.1016/j.mce.2008.09.038

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Journal:
Molecular and cellular endocrinology
Volume:
301
Issue:
1-2
Pages:
109-116
Publication date:
2009-03-01
DOI:
EISSN:
1872-8057
ISSN:
0303-7207
Source identifiers:
108757

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