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Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines.

Abstract:

The effect of diazepam on brain 5-HT-mediated neuroendocrine responses was studied in healthy male volunteers. An acute dose of diazepam (15 mg) significantly attenuated the prolactin and growth hormone responses to intravenous L-tryptophan. After 3 weeks administration of diazepam (25 mg/d) these responses had returned to normal despite much higher plasma diazepam concentrations, suggesting that tolerance had occurred. A reduction in brain 5-HT function may underlie some of the acute therape...

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Publication status:
Published

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Journal:
Psychological medicine
Volume:
17
Issue:
3
Pages:
601-607
Publication date:
1987-08-05
EISSN:
1469-8978
ISSN:
0033-2917
URN:
uuid:5505f22e-fe66-4e70-890e-1e1d2e3b3f1f
Source identifiers:
185921
Local pid:
pubs:185921

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