Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines.

Nutt, DJ; Cowen, PJ

Abstract:

The effect of diazepam on brain 5-HT-mediated neuroendocrine responses was studied in healthy male volunteers. An acute dose of diazepam (15 mg) significantly attenuated the prolactin and growth hormone responses to intravenous L-tryptophan. After 3 weeks administration of diazepam (25 mg/d) these responses had returned to normal despite much higher plasma diazepam concentrations, suggesting that tolerance had occurred. A reduction in brain 5-HT function may underlie some of the acute therape...

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APA Style

Nutt, D. J., & Cowen, P. J. (1987). Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines. Psychological Medicine, 17(3), 601–607.

MLA Style

Nutt, D. J., and P. J. Cowen. “Diazepam Alters Brain 5-HT Function in Man: Implications for the Acute and Chronic Effects of Benzodiazepines.” Psychological Medicine, vol. 17, no. 3, 1987, pp. 601–07.

Chicago Style

Nutt, DJ, and PJ Cowen. 1987. “Diazepam Alters Brain 5-HT Function in Man: Implications for the Acute and Chronic Effects of Benzodiazepines.” Psychological Medicine 17 (3): 601–7.
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