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HIV-1 RNA may decline more slowly in semen than in blood following initiation of efavirenz-based antiretroviral therapy.

Abstract:

OBJECTIVES: Antiretroviral therapy (ART) decreases HIV-1 RNA levels in semen and reduces sexual transmission from HIV-1-infected men. Our objective was to study the time course and magnitude of seminal HIV-1 RNA decay after initiation of efavirenz-based ART among 13 antiretroviral-naïve Kenyan men. METHODS: HIV-1 RNA was quantified (lower limit of detection, 120 copies/mL) in blood and semen at baseline and over the first month of ART. Median log(10) HIV-1 RNA was compared at each time-point ...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0043086

Authors


Graham, SM More by this author
Dragavon, JA More by this author
Mandaliya, KN More by this author
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Journal:
PloS one
Volume:
7
Issue:
8
Pages:
e43086
Publication date:
2012
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:5501e07f-7ca7-46fd-8c7b-e198f4caec7b
Source identifiers:
350027
Local pid:
pubs:350027

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