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Thesis

Evolutionary Insights Into Oxygen Sensing

Abstract:

In humans, cellular oxygen sensing employs the Hypoxia Inducible Factor (HIF) system in which the prolyl hydroxylase domain containing (PHD) and Factor Inhibiting HIF (FIH) oxygenases play a key role. The oxygen sensing mechanism enabled by the HIF hydroxylases has been extensively studied in humans and other mammals; how ‘lower’ organisms, such as protists and bacteria sense oxygen is less well understood. The social amoeba, Dictyostelium discoideum, and the protozoan parasite,...

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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