Thesis icon

Thesis

Exploring the roles of LIM domain binding proteins in zebrafish development

Abstract:

As some of the most important and widely utilised intercellular signalling molecules, transforming growth factor βs (TGFβs) play critical roles in normal development and in human disease. Establishing appropriate levels of signalling involves positive and negative feedback, driven by the same signal transduction components, but whether or how the two are distinguished has not previously been understood. Here we show that LIM domain binding proteins (Ldbs) drive the Smad6/7-mediated negativ...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Oxford college:
St Edmund Hall
Department:
Medical Sciences Division - Clinical Laboratory Sciences

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:54f520f6-170a-480a-a195-1a0739055031
Local pid:
ora:9616

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP