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Journal article

Fast and forceful refolding of stretched alpha-helical solenoid proteins.

Abstract:

Anfinsen's thermodynamic hypothesis implies that proteins can encode for stretching through reversible loss of structure. However, large in vitro extensions of proteins that occur through a progressive unfolding of their domains typically dissipate a significant amount of energy, and therefore are not thermodynamically reversible. Some coiled-coil proteins have been found to stretch nearly reversibly, although their extension is typically limited to 2.5 times their folded length. Here, we rep...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpj.2010.02.054

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Journal:
Biophysical journal
Volume:
98
Issue:
12
Pages:
3086-3092
Publication date:
2010-06-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:54eeb50b-a07c-436b-8340-cd998f297a64
Source identifiers:
60716
Local pid:
pubs:60716

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