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Journal article

Ion channels in genetic and acquired forms of epilepsy

Abstract:

Genetic mutations causing dysfunction of both voltage- and ligand-gated ion channels make a major contribution to the cause of many different types of familial epilepsy. Key mechanisms comprise defective Na+ channels of inhibitory neurons, or GABAA receptors affecting pre- or postsynaptic GABAergic inhibition, or a dysfunction of different types of channels at axon initial segments. Many of these ion channel mutations have been modelled in mice, which has largely contributed to the understand...

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Authors


Noebels, J More by this author
Johnston, D More by this author
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Journal:
Journal of Physiology
Volume:
591
Issue:
4
Pages:
753-764
Publication date:
2013-02-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:54eb61d4-86d3-4cac-b983-15524e6bb17f
Source identifiers:
388445
Local pid:
pubs:388445

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