Journal article icon

Journal article

Deubiquitination of FANCD2 is required for DNA crosslink repair.

Abstract:

Monoubiquitination of FANCD2 and PCNA promotes DNA repair. It causes chromatin accumulation of FANCD2 and facilitates PCNA's recruitment of translesion polymerases to stalled replication. USP1, a protease that removes monoubiquitin from FANCD2 and PCNA, was thought to reverse the DNA damage response of these substrates. We disrupted USP1 in chicken cells to dissect its role in a stable genetic system. USP1 ablation increases FANCD2 and PCNA monoubiquitination but unexpectedly results in DNA c...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Oestergaard, VH More by this author
Langevin, F More by this author
Kuiken, HJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Molecular Medicine
Expand authors...
Journal:
Molecular cell
Volume:
28
Issue:
5
Pages:
798-809
Publication date:
2007-12-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:54debf43-46dc-492a-951a-e6a5b3ac148d
Source identifiers:
175130
Local pid:
pubs:175130

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP