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Synthesis of isotopically labelled cardiolipins

Abstract:
A phosphotriester approach is used to access the complex phospholipid, cardiolipin (1) with polyunsaturated fatty acid chains. The synthetic method allows the specific incorporation of isotopic labels within the molecule and sets up the desired configuration at all three chiral centres which corresponds to the configuration of the natural phospholipid. Using such a methodology a range of pure optically active cardiolipin molecular species have been synthesized.
Publication status:
Published

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Authors


Duralski, AA More by this author
Spooner, PJR More by this author
Rankin, SE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
TETRAHEDRON LETTERS
Volume:
39
Issue:
12
Pages:
1607-1610
Publication date:
1998-03-19
DOI:
ISSN:
0040-4039
URN:
uuid:54dce32f-a663-49d4-8228-1530312d09e2
Source identifiers:
410509
Local pid:
pubs:410509
Language:
English

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