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Impaired pulmonary nitric oxide bioavailability in pulmonary tuberculosis: association with disease severity and delayed mycobacterial clearance with treatment.

Abstract:

BACKGROUND: Nitric oxide (NO), a key macrophage antimycobacterial mediator that ameliorates immunopathology, is measurable in exhaled breath in individuals with pulmonary tuberculosis. We investigated relationships between fractional exhale NO (FENO) and initial pulmonary tuberculosis severity, change during treatment, and relationship with conversion of sputum culture to negative at 2 months. METHODS: In Papua, we measured FENO in patients with pulmonary tuberculosis at baseline and serially...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jit248

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Journal:
The Journal of infectious diseases
Volume:
208
Issue:
4
Pages:
616-626
Publication date:
2013-08-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:54b66be1-b4fe-4146-832a-326f49654124
Source identifiers:
417312
Local pid:
pubs:417312

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