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Structural and Functional Studies of K2P Channels

Abstract:

Two-pore domain potassium channels (K2Ps) are a family of dimeric potassium channels responsible for regulation of cellular excitability. In 2012, crystal structures of TREK-2 were solved revealing this channel in two different conformational states. In the down state, transmembrane helices M2, 3 and 4 descend further into the cytoplasm than in the up state. This reveals two gaps (fenestrations) that link the membrane directly to the ion conduction pathway. However, the functional relevance ...

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Alexandra Mackenzie More by this author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Stephen Tucker
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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