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Sperm express a Ca2+-regulated NAADP synthase.

Abstract:

NAADP (nicotinic acid-adenine dinucleotide phosphate), the most potent Ca2+-mobilizing second messenger, is active in a wide range of organisms and cell types. Until now, all NAADP-producing enzymes have been thought to be members of the ADP-ribosyl cyclase family. ADP-ribosyl cyclases exhibit promiscuous substrate selectivity, synthesize a variety of products and are regulated in a limited manner, which may be non-physiological. In the present paper, we report the presence of an enzyme on th...

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Publication status:
Published

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Publisher copy:
10.1042/bj20071616

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
The Biochemical journal
Volume:
411
Issue:
1
Pages:
63-70
Publication date:
2008-04-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:54a1bfd8-6a2a-4f0d-a96b-c757bc94b7e9
Source identifiers:
106367
Local pid:
pubs:106367

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