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Targeted neurotechnology restores walking in humans with spinal cord injury

Abstract:

Spinal cord injury leads to severe locomotor deficits or even complete leg paralysis. Here we introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control of walking in individuals who had sustained a spinal cord injury more than four years ago and presented with permanent motor deficits or complete paralysis despite extensive rehabilitation. Using an implanted pulse generator with real-time triggering capabilities, we delivered trains of spatially selective sti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Files:
Publisher copy:
10.1038/s41586-018-0649-2

Authors


Wagner, FB More by this author
Mignardot, J-B More by this author
Le Goff-Mignardot, CG More by this author
Demesmaeker, R More by this author
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International Foundation for Research in Paraplegia More from this funder
Wings for Life More from this funder
Wyss Center for Neuroengineering More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
563
Issue:
7229
Pages:
65–71
Publication date:
2018-10-31
Acceptance date:
2018-10-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:940886
URN:
uri:549e6529-437c-4597-b8a5-521a1b4efbce
UUID:
uuid:549e6529-437c-4597-b8a5-521a1b4efbce
Local pid:
pubs:940886

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