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A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.

Abstract:

We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of individuals of European descent, with one cohort comprised of female twins donating samples longitudinally. Sample metabolite concentrations were quantified by (1)H NMR and tested for association with ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1002270

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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Role:
Author
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Funding agency for:
Nicholson, G
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Funding agency for:
Rantalainen, M
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Funding agency for:
Donnelly, P
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Funding agency for:
McCarthy, MI
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
7
Issue:
9
Pages:
e1002270
Publication date:
2011-09-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:549cff34-afc3-413b-a692-75fbf4dcc9b0
Source identifiers:
180417
Local pid:
pubs:180417

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