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Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations.

Abstract:

Drug resistance conferred by specific human immunodeficiency virus type 1 (HIV-1) pol gene mutations has been associated with clinical progression in HIV-infected patients receiving anti-retroviral therapy. This study examined drug susceptibilities and pol mutations of HIV-1 strains from patients treated for 1 year with zidovudine, didanosine (ddI), or zidovudine and ddI. Ten (42%) of 24 patients receiving combination therapy versus 8/26 (31%) receiving only zidovudine had HIV-1 strains with ...

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Publisher copy:
10.1093/infdis/169.4.722

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Journal:
The Journal of infectious diseases
Volume:
169
Issue:
4
Pages:
722-729
Publication date:
1994-04-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:549774f5-2ce6-42d5-aaf6-81ee2334af2b
Source identifiers:
67970
Local pid:
pubs:67970

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