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A simple method to correct for the design effect in systematic reviews of trials using paired dichotomous data.

Abstract:

BACKGROUND AND OBJECTIVES: In systematic reviews of interventions of studies where randomization was done by individual but data are paired (such as eyes, ears), it is necessary to account for the natural clustering present. The Cochrane Handbook suggests treating these as examples of cluster randomized trials. An incorrect analysis (without adjustment) would usually overestimate the precision of the estimate. We discuss a simple method of adjustment that deals with this problem. METHODS: Fr...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
Journal:
Journal of clinical epidemiology
Volume:
60
Issue:
9
Pages:
975-978
Publication date:
2007-09-01
DOI:
EISSN:
1878-5921
ISSN:
0895-4356
Source identifiers:
116270
Language:
English
Keywords:
Pubs id:
pubs:116270
UUID:
uuid:5492b6da-9264-4815-b189-5d5fdd23f592
Local pid:
pubs:116270
Deposit date:
2012-12-19

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