BACKGROUND AND OBJECTIVES: In systematic reviews of interventions of studies where randomization was done by individual but data are paired (such as eyes, ears), it is necessary to account for the natural clustering present. The Cochrane Handbook suggests treating these as examples of cluster randomized trials. An incorrect analysis (without adjustment) would usually overestimate the precision of the estimate. We discuss a simple method of adjustment that deals with this problem. METHODS: Fr...Expand abstract
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A simple method to correct for the design effect in systematic reviews of trials using paired dichotomous data.
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