Journal article icon

Journal article

Human foamy virus integrase fails to catalyse the integration of a circular DNA molecule containing an LTR junction sequence.

Abstract:

The presence of closed circular forms of the linear DNA genome of human foamy virus (HFV) has not been established. The ability of the HFV integrase (IN) to catalyse the integration of these circular forms (termed 2 long terminal repeat (LTR) circles) was investigated, with a view to producing a novel hybrid vector. To this end, a construct was made containing, in addition to the enhanced green fluorescent protein (eGFP) marker gene, the last 27 bp of the 3' U5 LTR region of HFV fused to the ...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/sj.gt.3301795

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Critchley, R More by this author
Vassaux, G More by this author
McClure, MO More by this author
Journal:
Gene therapy
Volume:
9
Issue:
19
Pages:
1326-1332
Publication date:
2002-10-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:547e5563-3681-4a3b-b8d2-d468f082e79f
Source identifiers:
237021
Local pid:
pubs:237021

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP