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Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.

Abstract:

Zn(2+)-dependent carbonic anhydrases (CA) catalyse the reversible hydration of carbon dioxide to bicarbonate and participate in diverse physiological processes, hence having manifold therapeutic potentials. Among the 15 human CAs with wide-ranging sub-cellular localisation and kinetic properties, CA VI is the only secretory isoform. The 1.9Å crystal structure of the human CA VI catalytic domain reveals a prototypical mammalian CA fold, and a novel dimeric arrangement as compared to previously...

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Publisher copy:
10.1016/j.bbrc.2012.02.038

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Journal:
Biochem Biophys Res Commun
Volume:
419
Issue:
3
Pages:
485-489
Publication date:
2012-03-16
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:54798ec7-aed4-4c4f-ac25-0a06574e53ce
Source identifiers:
313099
Local pid:
pubs:313099

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