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Carbohydrate chain terminators: rational design of novel carbohydrate-based antifungal agents.

Abstract:
(Chemical Equation Presented) The terminators. A chain-termination approach was employed to rationally design monosaccharide derivatives as inhibitors of chitin biosynthesis by replacement of the 4-hydroxyl group of N-acetyl glucosamine monomers. Antifungal activity was observed for a variety of acylated monosaccharide and oxazoline derivatives by means of fungal-spore germination and adhesion assays. © 2007 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/cbic.200700234

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Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
Role:
Author
Journal:
Chembiochem : a European journal of chemical biology
Volume:
8
Issue:
11
Pages:
1241-1245
Publication date:
2007-07-05
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
URN:
uuid:5475ca6b-7501-4b3b-82eb-18b1f8ad1428
Source identifiers:
33896
Local pid:
pubs:33896

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