- (Chemical Equation Presented) The terminators. A chain-termination approach was employed to rationally design monosaccharide derivatives as inhibitors of chitin biosynthesis by replacement of the 4-hydroxyl group of N-acetyl glucosamine monomers. Antifungal activity was observed for a variety of acylated monosaccharide and oxazoline derivatives by means of fungal-spore germination and adhesion assays. © 2007 Wiley-VCH Verlag GmbH and Co. KGaA.
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Carbohydrate chain terminators: rational design of novel carbohydrate-based antifungal agents.
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