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Limited polymorphism of the Kelch propeller domain in Plasmodium malariae and P. ovale isolates from Thailand.

Abstract:

Artemisinin resistance in Plasmodium falciparum, the agent of severe malaria, is currently a major obstacle to malaria control in Southeast Asia. A gene named "kelch13" has been associated with artemisinin resistance in P. falciparum The orthologue of the kelch gene in P. vivax was identified and a small number of mutations were found in previous studies. The kelch orthologues in the other two human malaria parasites, P. malariae and P. ovale, have not yet been studied. Therefore, in this stu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/aac.00138-16

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Role:
Author
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Wellcome Trust More from this funder
Mahidol University More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
60
Issue:
7
Pages:
4055-4062
Publication date:
2016-04-05
Acceptance date:
2016-04-18
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pubs id:
pubs:619879
URN:
uri:54700117-69ae-4bff-9442-5c2e46b0489a
UUID:
uuid:54700117-69ae-4bff-9442-5c2e46b0489a
Local pid:
pubs:619879

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