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Catalytic properties of ADAM12 and its domain deletion mutants.

Abstract:

Human ADAM12 (a disintegrin and metalloproteinase) is a multidomain zinc metalloproteinase expressed at high levels during development and in human tumors. ADAM12 exists as two splice variants: a classical type 1 membrane-anchored form (ADAM12-L) and a secreted splice variant (ADAM12-S) consisting of pro, catalytic, disintegrin, cysteine-rich, and EGF domains. Here we present a novel activity of recombinant ADAM12-S and its domain deletion mutants on S-carboxymethylated transferrin (Cm-Tf). C...

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Publication status:
Published

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Publisher copy:
10.1021/bi701629c

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Journal:
Biochemistry
Volume:
47
Issue:
2
Pages:
537-547
Publication date:
2008-01-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Source identifiers:
226364

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